Record Details
Abstract
Incidence of acute lymphocytic leukemia (ALL) among children under 5 years of age was examined utilizing data from 24 population-based cancer registries in the United States. Age-specific incidence rates for ALL (and for comparison, acute nonlymphocytic leukemia [ANLL] and non-Hodgkin’s lymphoma [NHL]) among white children under 5 years of age were compared across four levels of urbanization: large and small metropolitan counties, and adjacent and nonadjacent rural counties. Among white males, incidence of ALL decreased with decreasing degrees of urbanization (two-sided trend P = 0.008), such that rates were significantly lower in the most remote rural counties than in the most populous metropolitan counties (RR = 0.71, CI = 0.59-0.85). No rural-urban gradient in the incidence of ALL was observed among white females, nor was any such gradient in incidence of ANLL or NHL detected among whites of either gender. Rates among blacks and Asians/Pacific Islanders (APIs) residing in metropolitan counties were also compared; blacks had lower incidence of ALL than white persons, and API persons had a lower incidence of ALL than white persons (RR = 0.78, CI = 0.63-0.97). Regardless of race, males had higher incidence of ALL than females, while ANLL rates did not vary by gender.
Keywords
Keyword |
acute
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children
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incidence
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leukemia
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lymphocytic
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united states
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urban
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