Record Details

Title Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002
Author Goodman, MT
Secondary Authors Yamamoto J
Publication Type (Help) article
Journal Cancer Causes Control
Month May
Year 2007
Pages 415-22
Volume 18
Number 4
Note DOI: 10.1007/s10552-006-0109-4
PubMed ID 17264972
EPub Date 2007 Jan 30
Citation Goodman MT, Yamamoto J. Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002. Cancer Causes Control. 2007 May;18(4):415-22. EPub 2007 Jan 30. PMID 17264972. []


Few investigations of biliary tract (gallbladder, extrahepatic bile duct, ampulla of Vater) cancers have been conducted because of the relative rarity of these malignancies. The objective of this analysis was to compare the demographic, pathological, and clinical features of biliary tract cancers among men and women. Biliary tract cancers among 11,261 men and 15,722 women were identified through 33 U.S. population-based registries during the period 1997-2002. These registries were estimated to represent 61% of the U.S. population. Age-adjusted incidence rates (AAIR) were calculated per 100,000 population using counts derived from the 2000 U.S. Census. The AAIR for gallbladder cancer among men (0.82 per 100,000) was significantly lower than the AAIR among women (1.45 per 100,000). By contrast, rates for extrahepatic bile duct and ampullary cancers were significantly higher among men (0.93 per 100,000 and 0.70 per 100,000, respectively) than among women (0.61 per 100,000 and 0.45 per 100,000, respectively). White men and women had significantly lower AAIRs for gallbladder cancer compared with other racial-ethnic groups, with the highest rates among Hispanics, American Indian-Alaska Natives, and Asian-Pacific Islanders(API). API and Hispanics of both sexes had the highest AAIRs for extrahepatic bile duct and ampullary cancers. Ampullary tumors were more likely to be diagnosed at a localized or regional stage than were cancers of the gallbladder and extrahepatic bile duct. API men and women tended to have more unstaged cancers than other groups. This population-based study suggests distinct etiologies of anatomic subsites of biliary tract cancer and caution against analytic investigations of all biliary tract cancers combined.


bile duct
united states